To study the differences and similarities between fine observation and conventional observation in fog microstructure, a systematic field observation of fog was conducted and lasted 58 days in Donghai, Lianyungang during the winter of 2020. Two fog monitors with different frequencies (5Hz and 1Hz) were applied simultaneously for measuring a radiation fog on December 28, 2020. Based on this observation, we found that compared with the 1Hz data, the 5Hz measurement observed more extreme values. In terms of the whole fog process, the results of the 5Hz fog droplet spectrometer averaged into 1Hz are less similar to the original results of 1Hz in the fog generation and dissipation stages, and more similar in the fog maturation and development stages. In terms of the spectral patterns, the spectral patterns of 5 Hz and 1 Hz are similar, while the main differences appear at the peak. The measurements of 5 Hz and 1 Hz can both reflect the relationship between the microphysics at different stages of this fog process, and the main differences appear at the fog generation stage. This may be due to the relatively small number of activation and condensation growth of new fog droplets observed at 5Hz at this stage.