Southeast Asia has a complex topography and a large population. The response of extreme precipitation events to global warming is sensitive and its future evolutionary characteristics are widely valued. In this study, 26 global climate models (GCMs) are used to present projected change in precipitation extremes over Southeast Asia at the end of 21st century based on the Coupled Model Intercomparison Project phase 6 (CMIP6) simulations. The thermodynamic and dynamic contributions to future changes in precipitation are analyzed by decomposition of moisture budget equation. The multi-model ensemble medians show that, compared with the historical reference period (1985—2014), the frequency and intensity of climatological precipitation and precipitation extremes in most of Southeast Asia are obviously increased at the end of 21st century (2070—2099) under SSP2-4.5 and SSP5-8.5 scenarios. The variation of precipitation extremes shows significant spatial differences under the global warming. Precipitation extremes with short duration and high intensity will occur in the Kalimantan. In southern Sumatra, the total precipitation of wet days (PRCPTOT) tends to decrease significantly and the occurrence of consecutive dry days (CDD) become more frequent. Except for heavy precipitation days (R10mm), the change of extreme precipitation indices with more pronounced magnitudes under SSP5-8.5 scenario than SSP2-4.5 scenario. The contribution rate of heavy precipitation (R95pTOT) increased by 22% (41%) under SSP2-4.5 (SSP5-8.5) scenario. Quantitative analysis of moisture budget equation shows that, thermodynamic and dynamic effects mainly result in the precipitation climatological changes at the end of 21st century. Compared with the large-scale circulation changes, the thermodynamic component with higher inter-model consistency is the main contribution term. Under SSP2-4.5 (SSP5-8.5) scenario, the contribution of thermodynamic effects accounts for 65% (64%) of the P-E (precipitation minus evaporation) changes. However, the dynamic effects show a counteracting trend to the changes of P-E, which contributes 35% (36%). Moisture convergence caused by atmospheric specific humidity changes is considered as the dominating factor of projected precipitation increase.