This paper is the outcome of the research on the way Tibetan Plateau(TP) regulates regional energetic processes and global climate,which is a key project sponsored by NSFC.The results can be summarized as follows.The concept of Tibetan-Iranian Plateau coupling system(TIPS) was proposed,which was characterized by a unique vertical motion over the Asian subtropical monsoon region.The TIPS was formed by surface sensible heating of the Iranian Plateau(IP) and TP as well as the interaction between them.Studies revealed the variability surface heat flux in TIPs and a unique cloud-precipitation-radiation structure over TP.The influence of TIPS on Asian summer monsoon,in view of astronomical and hydrological perspectives,was verified.Studies clarified the effect of TIPs on South Asian High,which led to warm upper troposphere and cool lower stratosphere.Their influences on northern hemisphere circulation,Indian Ocean air-sea interaction and the inter-annual variability of South Asian High were also explored.A new mechanism was proposed on how the plateau forced to trigger intense weather events in eastern China.The studies also revealed the physical proess of the cold surface temperature bias in CMIP5 models,which was a result of dynamical coupling between atmospheric circulation and snow albedo.