The Three Rivers Headwaters' Region is significant and sensitive to climate change,which is characterized with "warmth and wetness".From such perspectives as spatial pattern,climate extreme indices and comparison among regional-global climate variations,characteristics of climate variations and climate extremes in the Three Rivers' Headwaters Region over the Tibetan Plateau from 1961 to 2019 was studied.Temperature and precipitation observation data were obtained from 20 meteorological stations of China Meteorological Administration,HadCRUT4 as well as NOAA Precipitation Reconstruction datasets.It was revealed that the spatial averaged warming rate was 0.37℃/(10 a),which was more than the global average level (0.16℃/(10 a)) during the past 60 years and was also significantly higher than that in the same latitude (0.19℃/(10 a)) and in China (0.28℃/(10 a)).Under the background of global warming,most of the extreme climate indices in the Three Rivers' Headwaters Region have risen,and the most significant one is night extreme high temperature (0.55℃/(10 a)),suggesting the extremeness of regional climate has strengthened.The spatial pattern of temperature and precipitation during the past 60 years shows a positive gradient along the northwest-southeast direction,and its variation is characterized by a rising trend in the spatial differentiation of warming and humidification from west to east.Furthermore,the temporal-spatial patterns of climate change and climate extremes in the Three Rivers' Headwaters Region can provide some bases for research on the vulnerability of climate systems and ecosystems in this region.At the same time,this study also provides a comparative case for studies on the response of climate-sensitive alpine regions to global warming.